RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

We describe a system to evaluate the function of lymphocyte-specific and generally expressed genes in the differentiation and/or function of lymphocytes. RAG-2 (recombination-activating gene 2)-deficient mice have no mature B and T lymphocytes due to the inability to initiate VDJ recombination. Blas...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Chen, J, Lansford, R, Stewart, V, Young, F, Alt, F W
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46545/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8506294/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.10.4528
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