An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA

Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells. While F(ab′)(2) portions of DSA cause cellular activation and proliferation,...

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Vydáno v:Am J Transplant
Hlavní autoři: Thomas, K A, Valenzuela, N M, Gjertson, D, Mulder, A, Fishbein, M C, Parry, G C, Panicker, S, Reed, E F
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2015
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654252/
https://ncbi.nlm.nih.gov/pubmed/25904443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.13273
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