Effect of the Anti‐C1s Humanized Antibody TNT009 and Its Parental Mouse Variant TNT003 on HLA Antibody–Induced Complement Activation—A Preclinical In Vitro Study

The classic pathway (CP) of complement is believed to significantly contribute to alloantibody‐mediated transplant injury, and targeted complement inhibition is currently considered to be a promising approach for preventing rejection. Here, we investigated the mode of action and efficacy of the huma...

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Detalles Bibliográficos
Publicado en:Am J Transplant
Main Authors: Wahrmann, M., Mühlbacher, J., Marinova, L., Regele, H., Huttary, N., Eskandary, F., Cohen, G., Fischer, G. F., Parry, G. C., Gilbert, J. C., Panicker, S., Böhmig, G. A.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600102/
https://ncbi.nlm.nih.gov/pubmed/28251805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.14256
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