Complement-Mediated Enhancement of Monocyte Adhesion to Endothelial Cells by HLA Antibodies, and Blockade by a Specific Inhibitor of the Classical Complement Cascade, TNT003

BACKGROUND: Antibody-mediated rejection (AMR) of most solid organs is characterized by evidence of complement activation and/or intragraft macrophages (C4d + and CD68+ biopsies). We previously demonstrated that crosslinking of HLA I by antibodies triggered endothelial activation and monocyte adhesio...

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Detalhes bibliográficos
Publicado no:Transplantation
Main Authors: Valenzuela, Nicole M., Thomas, Kimberly A., Mulder, Arend, Parry, Graham C., Panicker, Sandip, Reed, Elaine F.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2017
Assuntos:
Original Basic Science—General
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482566/
https://ncbi.nlm.nih.gov/pubmed/28640789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000001486
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