Blockade of HLA Antibody-Triggered Classical Complement Activation in Sera From Subjects Dosed With the Anti-C1s Monoclonal Antibody TNT009—Results from a Randomized First-in-Human Phase 1 Trial

BACKGROUND: Complement may play a key role in antibody-mediated rejection. A promising therapeutic approach may be classical pathway (CP) inhibition at the level of early component C1. METHODS: In this first-in-human, double-blind, randomized placebo-controlled phase 1 trial, we evaluated the safety...

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Detalhes bibliográficos
Publicado no:Transplantation
Main Authors: Mühlbacher, Jakob, Jilma, Bernd, Wahrmann, Markus, Bartko, Johann, Eskandary, Farsad, Schörgenhofer, Christian, Schwameis, Michael, Parry, Graham C., Gilbert, James C., Panicker, Sandip, Böhmig, Georg A.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2017
Assuntos:
Original Clinical Science—General
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610566/
https://ncbi.nlm.nih.gov/pubmed/28926521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000001804
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