Pathways Disrupted in Human ALS Motor Neurons Identified Through Genetic Correction of Mutant SOD1

Although many distinct mutations in a variety of genes are known to cause Amyotrophic Lateral Sclerosis (ALS), it remains poorly understood how they selectively impact motor neuron biology and whether they converge on common pathways to cause neuronal degeneration. Here, we have combined reprogrammi...

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Bibliografske podrobnosti
izdano v:Cell Stem Cell
Main Authors: Kiskinis, Evangelos, Sandoe, Jackson, Williams, Luis A., Boulting, Gabriella L., Moccia, Rob, Wainger, Brian J., Han, Steve, Peng, Theodore, Thams, Sebastian, Mikkilineni, Shravani, Mellin, Cassidy, Merkle, Florian T., Davis-Dusenbery, Brandi N., Ziller, Michael, Oakley, Derek, Ichida, Justin, Dicostanza, Stefania, Atwater, Nick, Maeder, Morgan L., Goodwin, Mathew J., Nemesh, James, Handsaker, Robert E., Paull, Daniel, Noggle, Scott, McCarroll, Steven A., Joung, J. Keith, Woolf, Clifford J., Brown, Robert H, Eggan, Kevin
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653065/
https://ncbi.nlm.nih.gov/pubmed/24704492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.03.004
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