Intrinsic Membrane Hyperexcitability of ALS Patient-Derived Motor Neurons

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor nervous system. We show using multi-electrode array and patch clamp recordings that hyperexcitability detected by clinical neurophysiological studies of ALS patients is recapitulated in induced pluripotent stem cel...

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書誌詳細
主要な著者: Wainger, Brian J., Kiskinis, Evangelos, Mellin, Cassidy, Wiskow, Ole, Han, Steve S.W., Sandoe, Jackson, Perez, Numa P., Williams, Luis A., Lee, Seungkyu, Boulting, Gabriella, Berry, James D., Brown, Robert H., Cudkowicz, Merit E., Bean, Bruce P., Eggan, Kevin, Woolf, Clifford J.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023477/
https://ncbi.nlm.nih.gov/pubmed/24703839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.03.019
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