Identification of siRNA delivery enhancers by a chemical library screen

Most delivery systems for small interfering RNA therapeutics depend on endocytosis and release from endo-lysosomal compartments. One approach to improve delivery is to identify small molecules enhancing these steps. It is unclear to what extent such enhancers can be universally applied to different...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Gilleron, Jerome, Paramasivam, Prasath, Zeigerer, Anja, Querbes, William, Marsico, Giovanni, Andree, Cordula, Seifert, Sarah, Amaya, Pablo, Stöter, Martin, Koteliansky, Victor, Waldmann, Herbert, Fitzgerald, Kevin, Kalaidzidis, Yannis, Akinc, Akin, Maier, Martin A., Manoharan, Muthiah, Bickle, Marc, Zerial, Marino
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652771/
https://ncbi.nlm.nih.gov/pubmed/26220182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv762
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