Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction

The BH3-only protein Bim is a potent direct activator of the proapoptotic effector protein Bax, but the structural basis for its activity has remained poorly defined. Here we describe the crystal structure of the BimBH3 peptide bound to BaxΔC26 and structure-based mutagenesis studies. Similar to Bid...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Robin, A Y, Krishna Kumar, K, Westphal, D, Wardak, A Z, Thompson, G V, Dewson, G, Colman, P M, Czabotar, P E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650713/
https://ncbi.nlm.nih.gov/pubmed/26158515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.141
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