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Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction
The BH3-only protein Bim is a potent direct activator of the proapoptotic effector protein Bax, but the structural basis for its activity has remained poorly defined. Here we describe the crystal structure of the BimBH3 peptide bound to BaxΔC26 and structure-based mutagenesis studies. Similar to Bid...
में बचाया:
| में प्रकाशित: | Cell Death Dis |
|---|---|
| मुख्य लेखकों: | , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group
2015
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4650713/ https://ncbi.nlm.nih.gov/pubmed/26158515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.141 |
| टैग : |
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