Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo

Malignant glioma is a severe type of brain tumor with a poor prognosis and few options for therapy. The main chemotherapy protocol for this type of tumor is based on temozolomide (TMZ), albeit with limited success. Cisplatin is widely used to treat several types of tumor and, in association with TMZ...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Rocha, C R R, Garcia, C C M, Vieira, D B, Quinet, A, de Andrade-Lima, L C, Munford, V, Belizário, J E, Menck, C F M
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2014
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649538/
https://ncbi.nlm.nih.gov/pubmed/25356874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.465
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