Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo

Malignant glioma is a severe type of brain tumor with a poor prognosis and few options for therapy. The main chemotherapy protocol for this type of tumor is based on temozolomide (TMZ), albeit with limited success. Cisplatin is widely used to treat several types of tumor and, in association with TMZ...

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Publicat a:Cell Death Dis
Autors principals: Rocha, C R R, Garcia, C C M, Vieira, D B, Quinet, A, de Andrade-Lima, L C, Munford, V, Belizário, J E, Menck, C F M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649538/
https://ncbi.nlm.nih.gov/pubmed/25356874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.465
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