Depletion of Kruppel-like factor 15 sensitized gliomas to temozolomide cytotoxicity through O(6)-methylguanine-DNA methyl-transferase

Temozolomide (TMZ)-based chemotherapy is a standard strategy for gliomas, although chemoresistance remains a major therapeutic challenge. The chemical mechanism by which TMZ induces cell death is DNA methylation, leading to double-stranded breaks (DSBs) and thus to apoptosis. However, TMZ-induced N6...

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Gepubliceerd in:Biochem Biophys Rep
Hoofdauteurs: Qu, Xinjuan, Liu, Xuelai, Zhang, Yumei, Shi, Zhan, Wang, Xiaohua
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8242961/
https://ncbi.nlm.nih.gov/pubmed/34222684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2021.101058
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