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Depletion of Kruppel-like factor 15 sensitized gliomas to temozolomide cytotoxicity through O(6)-methylguanine-DNA methyl-transferase
Temozolomide (TMZ)-based chemotherapy is a standard strategy for gliomas, although chemoresistance remains a major therapeutic challenge. The chemical mechanism by which TMZ induces cell death is DNA methylation, leading to double-stranded breaks (DSBs) and thus to apoptosis. However, TMZ-induced N6...
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| Publicado no: | Biochem Biophys Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8242961/ https://ncbi.nlm.nih.gov/pubmed/34222684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2021.101058 |
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