O6-Methylguanine-Methyltransferase (MGMT) Promoter Methylation Status in Glioma Stem-Like Cells is Correlated to Temozolomide Sensitivity Under Differentiation-Promoting Conditions

Glioblastoma (GBM) is the most malignant type of primary brain tumor with a very poor prognosis. The actual standard protocol of treatment for GBM patients consists of radiotherapy and concomitant temozolomide (TMZ). However, the therapeutic efficacy of this treatment is limited due to tumor recurre...

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Detalhes bibliográficos
Main Authors: Villalva, Claire, Cortes, Ulrich, Wager, Michel, Tourani, Jean-Marc, Rivet, Pierre, Marquant, Celine, Martin, Sebastien, Turhan, Ali G., Karayan-Tapon, Lucie
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International (MDPI) 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397507/
https://ncbi.nlm.nih.gov/pubmed/22837675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms13066983
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