O6-Methylguanine-Methyltransferase (MGMT) Promoter Methylation Status in Glioma Stem-Like Cells is Correlated to Temozolomide Sensitivity Under Differentiation-Promoting Conditions

Glioblastoma (GBM) is the most malignant type of primary brain tumor with a very poor prognosis. The actual standard protocol of treatment for GBM patients consists of radiotherapy and concomitant temozolomide (TMZ). However, the therapeutic efficacy of this treatment is limited due to tumor recurre...

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Main Authors: Villalva, Claire, Cortes, Ulrich, Wager, Michel, Tourani, Jean-Marc, Rivet, Pierre, Marquant, Celine, Martin, Sebastien, Turhan, Ali G., Karayan-Tapon, Lucie
格式: Artigo
語言:Inglês
出版: Molecular Diversity Preservation International (MDPI) 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397507/
https://ncbi.nlm.nih.gov/pubmed/22837675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms13066983
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