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Dual MGMT inactivation by promoter hypermethylation and loss of the long arm of chromosome 10 in glioblastoma

BACKGROUND: Epigenetic inactivation of O6‐methylguanine‐methyltransferase (MGMT) gene by methylation of its promoter is predictive of Temozolomid (TMZ) response in glioblastoma (GBM). MGMT is located on chromosome 10q26 and the loss of chromosome 10q is observed in 70% of GBMs. In this study, we ass...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Richard, Sophie, Tachon, Gaëlle, Milin, Serge, Wager, Michel, Karayan‐Tapon, Lucie
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476845/
https://ncbi.nlm.nih.gov/pubmed/32666673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3217
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