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Dual MGMT inactivation by promoter hypermethylation and loss of the long arm of chromosome 10 in glioblastoma
BACKGROUND: Epigenetic inactivation of O6‐methylguanine‐methyltransferase (MGMT) gene by methylation of its promoter is predictive of Temozolomid (TMZ) response in glioblastoma (GBM). MGMT is located on chromosome 10q26 and the loss of chromosome 10q is observed in 70% of GBMs. In this study, we ass...
Gespeichert in:
| Veröffentlicht in: | Cancer Med |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7476845/ https://ncbi.nlm.nih.gov/pubmed/32666673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3217 |
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