Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy

The objective of this study was to investigate the risk of attenuated efficacy due to adaptive resistance for the siderophore-conjugated monocarbam SMC-3176 in Pseudomonas aeruginosa by using a pharmacokinetic/pharmacodynamic (PK/PD) approach. MICs were determined in cation-adjusted Mueller-Hinton b...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Kim, Aryun, Kutschke, Amy, Ehmann, David E., Patey, Sara A., Crandon, Jared L., Gorseth, Elise, Miller, Alita A., McLaughlin, Robert E., Blinn, Christina M., Chen, April, Nayar, Asha S., Dangel, Brian, Tsai, Andy S., Rooney, Michael T., Murphy-Benenato, Kerry E., Eakin, Ann E., Nicolau, David P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Experimental Therapeutics
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649189/
https://ncbi.nlm.nih.gov/pubmed/26438502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00831-15
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