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SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3

[Image: see text] A main challenge in the development of new agents for the treatment of Pseudomonas aeruginosa infections is the identification of chemotypes that efficiently penetrate the cell envelope and are not susceptible to established resistance mechanisms. Siderophore-conjugated monocarbams...

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Détails bibliographiques
Publié dans:ACS Med Chem Lett
Auteurs principaux: Murphy-Benenato, Kerry E., Dangel, Brian, Davis, Hajnalka E., Durand-Réville, Thomas F., Ferguson, Andrew D., Gao, Ning, Jahić, Haris, Mueller, John P., Manyak, Erika L., Quiroga, Olga, Rooney, Michael, Sha, Li, Sylvester, Mark, Wu, Frank, Zambrowski, Mark, Zhao, Shannon X.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2015
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434466/
https://ncbi.nlm.nih.gov/pubmed/26005529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00026
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