Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy

The objective of this study was to investigate the risk of attenuated efficacy due to adaptive resistance for the siderophore-conjugated monocarbam SMC-3176 in Pseudomonas aeruginosa by using a pharmacokinetic/pharmacodynamic (PK/PD) approach. MICs were determined in cation-adjusted Mueller-Hinton b...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Kim, Aryun, Kutschke, Amy, Ehmann, David E., Patey, Sara A., Crandon, Jared L., Gorseth, Elise, Miller, Alita A., McLaughlin, Robert E., Blinn, Christina M., Chen, April, Nayar, Asha S., Dangel, Brian, Tsai, Andy S., Rooney, Michael T., Murphy-Benenato, Kerry E., Eakin, Ann E., Nicolau, David P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2015
Aiheet:
Experimental Therapeutics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649189/
https://ncbi.nlm.nih.gov/pubmed/26438502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00831-15
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