Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy

The objective of this study was to investigate the risk of attenuated efficacy due to adaptive resistance for the siderophore-conjugated monocarbam SMC-3176 in Pseudomonas aeruginosa by using a pharmacokinetic/pharmacodynamic (PK/PD) approach. MICs were determined in cation-adjusted Mueller-Hinton b...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Kim, Aryun, Kutschke, Amy, Ehmann, David E., Patey, Sara A., Crandon, Jared L., Gorseth, Elise, Miller, Alita A., McLaughlin, Robert E., Blinn, Christina M., Chen, April, Nayar, Asha S., Dangel, Brian, Tsai, Andy S., Rooney, Michael T., Murphy-Benenato, Kerry E., Eakin, Ann E., Nicolau, David P.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649189/
https://ncbi.nlm.nih.gov/pubmed/26438502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00831-15
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