Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy

The objective of this study was to investigate the risk of attenuated efficacy due to adaptive resistance for the siderophore-conjugated monocarbam SMC-3176 in Pseudomonas aeruginosa by using a pharmacokinetic/pharmacodynamic (PK/PD) approach. MICs were determined in cation-adjusted Mueller-Hinton b...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Kim, Aryun, Kutschke, Amy, Ehmann, David E., Patey, Sara A., Crandon, Jared L., Gorseth, Elise, Miller, Alita A., McLaughlin, Robert E., Blinn, Christina M., Chen, April, Nayar, Asha S., Dangel, Brian, Tsai, Andy S., Rooney, Michael T., Murphy-Benenato, Kerry E., Eakin, Ann E., Nicolau, David P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2015
Pynciau:
Experimental Therapeutics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649189/
https://ncbi.nlm.nih.gov/pubmed/26438502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00831-15
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