Hydroxyurea-Increased Fetal Hemoglobin Is Associated with Less Organ Damage and Longer Survival in Adults with Sickle Cell Anemia

BACKGROUND: Adults with sickle cell anemia (HbSS) are inconsistently treated with hydroxyurea. OBJECTIVES: We retrospectively evaluated the effects of elevating fetal hemoglobin with hydroxyurea on organ damage and survival in patients enrolled in our screening study between 2001 and 2010. METHODS:...

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Publié dans:PLoS One
Auteurs principaux: Fitzhugh, Courtney D., Hsieh, Matthew M., Allen, Darlene, Coles, Wynona A., Seamon, Cassie, Ring, Michael, Zhao, Xiongce, Minniti, Caterina P., Rodgers, Griffin P., Schechter, Alan N., Tisdale, John F., Taylor, James G.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
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Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648496/
https://ncbi.nlm.nih.gov/pubmed/26576059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141706
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