Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

The enzyme N-myristoyltransferase (NMT) from Trypanosoma brucei has been validated both chemically and biologically as a potential drug target for human African trypanosomiasis. We previously reported the development of some very potent compounds based around a pyrazole sulfonamide series, derived f...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:ChemMedChem
Autores principales: Spinks, Daniel, Smith, Victoria, Thompson, Stephen, Robinson, David A, Luksch, Torsten, Smith, Alasdair, Torrie, Leah S, McElroy, Stuart, Stojanovski, Laste, Norval, Suzanne, Collie, Iain T, Hallyburton, Irene, Rao, Bhavya, Brand, Stephen, Brenk, Ruth, Frearson, Julie A, Read, Kevin D, Wyatt, Paul G, Gilbert, Ian H
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2015
Materias:
Full Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648043/
https://ncbi.nlm.nih.gov/pubmed/26395087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500301
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares