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Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

The enzyme N-myristoyltransferase (NMT) from Trypanosoma brucei has been validated both chemically and biologically as a potential drug target for human African trypanosomiasis. We previously reported the development of some very potent compounds based around a pyrazole sulfonamide series, derived f...

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發表在:ChemMedChem
Main Authors: Spinks, Daniel, Smith, Victoria, Thompson, Stephen, Robinson, David A, Luksch, Torsten, Smith, Alasdair, Torrie, Leah S, McElroy, Stuart, Stojanovski, Laste, Norval, Suzanne, Collie, Iain T, Hallyburton, Irene, Rao, Bhavya, Brand, Stephen, Brenk, Ruth, Frearson, Julie A, Read, Kevin D, Wyatt, Paul G, Gilbert, Ian H
格式: Artigo
語言:Inglês
出版: Blackwell Publishing Ltd 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648043/
https://ncbi.nlm.nih.gov/pubmed/26395087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500301
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