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Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

The enzyme N-myristoyltransferase (NMT) from Trypanosoma brucei has been validated both chemically and biologically as a potential drug target for human African trypanosomiasis. We previously reported the development of some very potent compounds based around a pyrazole sulfonamide series, derived f...

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Publicat a:ChemMedChem
Autors principals: Spinks, Daniel, Smith, Victoria, Thompson, Stephen, Robinson, David A, Luksch, Torsten, Smith, Alasdair, Torrie, Leah S, McElroy, Stuart, Stojanovski, Laste, Norval, Suzanne, Collie, Iain T, Hallyburton, Irene, Rao, Bhavya, Brand, Stephen, Brenk, Ruth, Frearson, Julie A, Read, Kevin D, Wyatt, Paul G, Gilbert, Ian H
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648043/
https://ncbi.nlm.nih.gov/pubmed/26395087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500301
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