Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds

BACKGROUND: Exportin 1 (XPO1) is a well-characterized nuclear export protein whose expression is up-regulated in many types of cancers and functions to transport key tumor suppressor proteins (TSPs) from the nucleus. Karyopharm Therapeutics has developed a series of small-molecule Selective Inhibito...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Crochiere, Marsha, Kashyap, Trinayan, Kalid, Ori, Shechter, Sharon, Klebanov, Boris, Senapedis, William, Saint-Martin, Jean-Richard, Landesman, Yosef
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647283/
https://ncbi.nlm.nih.gov/pubmed/26573568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1790-z
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