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An Aggregation Advisor for Ligand Discovery

Colloidal aggregation of organic molecules is the dominant mechanism for artifactual inhibition of proteins, and controls against it are widely deployed. Notwithstanding an increasingly detailed understanding of this phenomenon, a method to reliably predict aggregation has remained elusive. Correspo...

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Bibliografische gegevens
Gepubliceerd in:J Med Chem
Hoofdauteurs: Irwin, John J., Duan, Da, Torosyan, Hayarpi, Doak, Allison K., Ziebart, Kristin T., Sterling, Teague, Tumanian, Gurgen, Shoichet, Brian K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646424/
https://ncbi.nlm.nih.gov/pubmed/26295373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01105
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