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Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling
The G protein-coupled receptor GHS-R1a mediates ghrelin-induced growth hormone secretion, food intake, and reward-seeking behaviors. GHS-R1a signals through G(q), G(i/o), G(13), and arrestin. Biasing GHS-R1a signaling with specific ligands may lead to the development of more selective drugs to treat...
Sparad:
| I publikationen: | J Biol Chem |
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| Huvudupphovsmän: | , , , , , , , , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Biochemistry and Molecular Biology
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4646384/ https://ncbi.nlm.nih.gov/pubmed/26363071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.659250 |
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