Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

How G protein-coupled receptor conformational dynamics control G protein coupling to trigger signaling is a key but still open question. We addressed this question with a model system composed of the purified ghrelin receptor assembled into lipid discs. Combining receptor labeling through genetic in...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Damian, Marjorie, Mary, Sophie, Maingot, Mathieu, M'Kadmi, Céline, Gagne, Didier, Leyris, Jean-Philippe, Denoyelle, Séverine, Gaibelet, Gérald, Gavara, Laurent, Garcia de Souza Costa, Mauricio, Perahia, David, Trinquet, Eric, Mouillac, Bernard, Galandrin, Ségolène, Galès, Céline, Fehrentz, Jean-Alain, Floquet, Nicolas, Martinez, Jean, Marie, Jacky, Banères, Jean-Louis
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321262/
https://ncbi.nlm.nih.gov/pubmed/25605885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414618112
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