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Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex
How G protein-coupled receptor conformational dynamics control G protein coupling to trigger signaling is a key but still open question. We addressed this question with a model system composed of the purified ghrelin receptor assembled into lipid discs. Combining receptor labeling through genetic in...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4321262/ https://ncbi.nlm.nih.gov/pubmed/25605885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414618112 |
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