Allosteric modulation of ghrelin receptor signaling by lipids

The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here we demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effects. We find that PIP2 shifts the conformational equili...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Damian, Marjorie, Louet, Maxime, Gomes, Antoniel Augusto Severo, M’Kadmi, Céline, Denoyelle, Séverine, Cantel, Sonia, Mary, Sophie, Bisch, Paulo M., Fehrentz, Jean-Alain, Catoire, Laurent J., Floquet, Nicolas, Banères, Jean-Louis
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225672/
https://ncbi.nlm.nih.gov/pubmed/34168117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23756-y
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