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Allosteric modulation of ghrelin receptor signaling by lipids
The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here we demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effects. We find that PIP2 shifts the conformational equili...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8225672/ https://ncbi.nlm.nih.gov/pubmed/34168117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23756-y |
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