Allosteric modulation of ghrelin receptor signaling by lipids

The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here we demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effects. We find that PIP2 shifts the conformational equili...

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Vydáno v:Nat Commun
Hlavní autoři: Damian, Marjorie, Louet, Maxime, Gomes, Antoniel Augusto Severo, M’Kadmi, Céline, Denoyelle, Séverine, Cantel, Sonia, Mary, Sophie, Bisch, Paulo M., Fehrentz, Jean-Alain, Catoire, Laurent J., Floquet, Nicolas, Banères, Jean-Louis
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225672/
https://ncbi.nlm.nih.gov/pubmed/34168117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23756-y
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