Allosteric modulation of ghrelin receptor signaling by lipids

The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here we demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effects. We find that PIP2 shifts the conformational equili...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Damian, Marjorie, Louet, Maxime, Gomes, Antoniel Augusto Severo, M’Kadmi, Céline, Denoyelle, Séverine, Cantel, Sonia, Mary, Sophie, Bisch, Paulo M., Fehrentz, Jean-Alain, Catoire, Laurent J., Floquet, Nicolas, Banères, Jean-Louis
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225672/
https://ncbi.nlm.nih.gov/pubmed/34168117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23756-y
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