Structure and dynamics of G protein-coupled receptor–bound ghrelin reveal the critical role of the octanoyl chain

Ghrelin plays a central role in controlling major biological processes. As for other G protein-coupled receptor (GPCR) peptide agonists, the structure and dynamics of ghrelin bound to its receptor remain obscure. Using a combination of solution-state NMR and molecular modeling, we demonstrate that b...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Ferré, Guillaume, Louet, Maxime, Saurel, Oliver, Delort, Bartholomé, Czaplicki, Georges, M’Kadmi, Céline, Damian, Marjorie, Renault, Pedro, Cantel, Sonia, Gavara, Laurent, Demange, Pascal, Marie, Jacky, Fehrentz, Jean-Alain, Floquet, Nicolas, Milon, Alain, Banères, Jean-Louis
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717258/
https://ncbi.nlm.nih.gov/pubmed/31416915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905105116
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