High Constitutive Activity Is an Intrinsic Feature of Ghrelin Receptor Protein: A STUDY WITH A FUNCTIONAL MONOMERIC GHS-R1a RECEPTOR RECONSTITUTED IN LIPID DISCS

Despite its central role in signaling and the potential therapeutic applications of inverse agonists, the molecular mechanisms underlying G protein-coupled receptor (GPCR) constitutive activity remain largely to be explored. In this context, ghrelin receptor GHS-R1a is a peculiar receptor in the sen...

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Hlavní autoři: Damian, Marjorie, Marie, Jacky, Leyris, Jean-Philippe, Fehrentz, Jean-Alain, Verdié, Pascal, Martinez, Jean, Banères, Jean-Louis, Mary, Sophie
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281683/
https://ncbi.nlm.nih.gov/pubmed/22117076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.288324
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