Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation

Mitochondrial dysfunction is considered crucial for NLRP3 inflammasome activation partly through its release of mitochondrial toxic products, such as mitochondrial reactive oxygen species (mROS) and mitochondrial DNA (mtDNA). Although previous studies have shown that classical NLRP3-activating stimu...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Won, Ji-Hee, Park, Sangjun, Hong, Sujeong, Son, Seunghwan, Yu, Je-Wook
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646374/
https://ncbi.nlm.nih.gov/pubmed/26416893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.667063
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