MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and the reduction of dopamine levels in the striatum. Although details of the molecular mechanisms underlying dopaminergic neuronal death in PD rema...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Lee, Eunju, Hwang, Inhwa, Park, Sangjun, Hong, Sujeong, Hwang, Boreum, Cho, Yoeseph, Son, Junghyun, Yu, Je-Wook
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329843/
https://ncbi.nlm.nih.gov/pubmed/29786072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0124-5
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