Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation

Mitochondrial dysfunction is considered crucial for NLRP3 inflammasome activation partly through its release of mitochondrial toxic products, such as mitochondrial reactive oxygen species (mROS) and mitochondrial DNA (mtDNA). Although previous studies have shown that classical NLRP3-activating stimu...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Won, Ji-Hee, Park, Sangjun, Hong, Sujeong, Son, Seunghwan, Yu, Je-Wook
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646374/
https://ncbi.nlm.nih.gov/pubmed/26416893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.667063
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