APOBEC-induced cancer mutations are uniquely enriched in early replicating, gene dense, and active chromatin regions

An antiviral component of the human innate immune system - the APOBEC cytidine deaminases – was recently identified as a prominent source of mutations in cancers. Here, we investigated the distribution of APOBEC-induced mutations across the genomes of 119 breast and 24 lung cancer samples. While the...

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Udgivet i:Cell Rep
Main Authors: Kazanov, Marat D., Roberts, Steven A., Polak, Paz, Stamatoyannopoulos, John, Klimczak, Leszek J., Gordenin, Dmitry A., Sunyaev, Shamil R.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644490/
https://ncbi.nlm.nih.gov/pubmed/26527001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.077
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