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Cell-of-origin chromatin organization shapes the mutational landscape of cancer
Cancer is a disease potentiated by mutations in somatic cells. Cancer mutations are not distributed uniformly along the genome. Instead, different genomic regions vary by up to 5-fold in the local density of somatic mutations(1), posing a fundamental problem for statistical methods of cancer genomic...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4405175/ https://ncbi.nlm.nih.gov/pubmed/25693567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14221 |
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