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Cell-of-origin chromatin organization shapes the mutational landscape of cancer
Cancer is a disease potentiated by mutations in somatic cells. Cancer mutations are not distributed uniformly along the genome. Instead, different genomic regions vary by up to 5-fold in the local density of somatic mutations(1), posing a fundamental problem for statistical methods of cancer genomic...
Enregistré dans:
| Publié dans: | Nature |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4405175/ https://ncbi.nlm.nih.gov/pubmed/25693567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14221 |
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