Cell-of-origin chromatin organization shapes the mutational landscape of cancer

Cancer is a disease potentiated by mutations in somatic cells. Cancer mutations are not distributed uniformly along the genome. Instead, different genomic regions vary by up to 5-fold in the local density of somatic mutations(1), posing a fundamental problem for statistical methods of cancer genomic...

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Bibliografische gegevens
Gepubliceerd in:Nature
Hoofdauteurs: Polak, Paz, Karlić, Rosa, Koren, Amnon, Thurman, Robert, Sandstrom, Richard, Lawrence, Michael, Reynolds, Alex, Rynes, Eric, Vlahoviček, Kristian, Stamatoyannopoulos, John A., Sunyaev, Shamil R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405175/
https://ncbi.nlm.nih.gov/pubmed/25693567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14221
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