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APOBEC-induced cancer mutations are uniquely enriched in early replicating, gene dense, and active chromatin regions
An antiviral component of the human innate immune system - the APOBEC cytidine deaminases – was recently identified as a prominent source of mutations in cancers. Here, we investigated the distribution of APOBEC-induced mutations across the genomes of 119 breast and 24 lung cancer samples. While the...
Gorde:
| Argitaratua izan da: | Cell Rep |
|---|---|
| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4644490/ https://ncbi.nlm.nih.gov/pubmed/26527001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.077 |
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