Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases

Yeast strains with low levels of the replicative DNA polymerases (alpha, delta, and epsilon) have high levels of chromosome deletions, duplications, and translocations. By examining the patterns of mutations induced in strains with low levels of DNA polymerase by the human protein APOBEC3B (a protei...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Sui, Yang, Qi, Lei, Zhang, Ke, Saini, Natalie, Klimczak, Leszek J., Sakofsky, Cynthia J., Gordenin, Dmitry A., Petes, Thomas D., Zheng, Dao-Qiong
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196835/
https://ncbi.nlm.nih.gov/pubmed/32277034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922472117
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