Mutation signatures specific to DNA alkylating agents in yeast and cancers

Alkylation is one of the most ubiquitous forms of DNA lesions. However, the motif preferences and substrates for the activity of the major types of alkylating agents defined by their nucleophilic substitution reactions (S(N)1 and S(N)2) are still unclear. Utilizing yeast strains engineered for large...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Saini, Natalie, Sterling, Joan F, Sakofsky, Cynthia J, Giacobone, Camille K, Klimczak, Leszek J, Burkholder, Adam B, Malc, Ewa P, Mieczkowski, Piotr A, Gordenin, Dmitry A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144945/
https://ncbi.nlm.nih.gov/pubmed/32133535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa150
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