Mutation signatures specific to DNA alkylating agents in yeast and cancers

Alkylation is one of the most ubiquitous forms of DNA lesions. However, the motif preferences and substrates for the activity of the major types of alkylating agents defined by their nucleophilic substitution reactions (S(N)1 and S(N)2) are still unclear. Utilizing yeast strains engineered for large...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Saini, Natalie, Sterling, Joan F, Sakofsky, Cynthia J, Giacobone, Camille K, Klimczak, Leszek J, Burkholder, Adam B, Malc, Ewa P, Mieczkowski, Piotr A, Gordenin, Dmitry A
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144945/
https://ncbi.nlm.nih.gov/pubmed/32133535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa150
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