Mutation signatures specific to DNA alkylating agents in yeast and cancers

Alkylation is one of the most ubiquitous forms of DNA lesions. However, the motif preferences and substrates for the activity of the major types of alkylating agents defined by their nucleophilic substitution reactions (S(N)1 and S(N)2) are still unclear. Utilizing yeast strains engineered for large...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Saini, Natalie, Sterling, Joan F, Sakofsky, Cynthia J, Giacobone, Camille K, Klimczak, Leszek J, Burkholder, Adam B, Malc, Ewa P, Mieczkowski, Piotr A, Gordenin, Dmitry A
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144945/
https://ncbi.nlm.nih.gov/pubmed/32133535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa150
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