Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature

Redox stress is a major hallmark of cancer. Analysis of thousands of sequenced cancer exomes and whole genomes revealed distinct mutational signatures that can be attributed to specific sources of DNA lesions. Clustered mutations discovered in several cancer genomes were linked to single-strand DNA...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PLoS Biol
Hauptverfasser: Degtyareva, Natalya P., Saini, Natalie, Sterling, Joan F., Placentra, Victoria C., Klimczak, Leszek J., Gordenin, Dmitry A., Doetsch, Paul W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527239/
https://ncbi.nlm.nih.gov/pubmed/31067233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000263
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge