Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines

Localized hyper-mutability caused by accumulation of lesions in persistent single-stranded (ss) DNA has been recently found in several types of cancers. An increase in endogenous levels of reactive oxygen species (ROS) is considered to be one of the hallmarks of cancers. Employing a yeast model syst...

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Detalles Bibliográficos
Main Authors: Degtyareva, Natalya P., Heyburn, Lanier, Sterling, Joan, Resnick, Michael A., Gordenin, Dmitry A., Doetsch, Paul W.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799438/
https://ncbi.nlm.nih.gov/pubmed/23925127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt671
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