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Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation
A single cancer genome can harbor thousands of clustered mutations. Mutation signature analyses have revealed that the origin of clusters are lesions in long tracts of single-stranded (ss) DNA damaged by apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) cytidine deaminases, r...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | PLoS Biol |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Public Library of Science
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6786661/ https://ncbi.nlm.nih.gov/pubmed/31568516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000464 |
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