Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation

A single cancer genome can harbor thousands of clustered mutations. Mutation signature analyses have revealed that the origin of clusters are lesions in long tracts of single-stranded (ss) DNA damaged by apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) cytidine deaminases, r...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Biol
Auteurs principaux: Sakofsky, Cynthia J., Saini, Natalie, Klimczak, Leszek J., Chan, Kin, Malc, Ewa P., Mieczkowski, Piotr A., Burkholder, Adam B., Fargo, David, Gordenin, Dmitry A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786661/
https://ncbi.nlm.nih.gov/pubmed/31568516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000464
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