Break-Induced Replication is a Source of Mutation Clusters Underlying Kataegis

Clusters of simultaneous multiple mutations can be a source of rapid change during carcinogenesis and evolution. Such mutation clusters have been recently shown to originate from DNA damage within long single-strand (ss) DNA formed at resected double-strand breaks and dysfunctional replication forks...

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Publicado en:Cell Rep
Main Authors: Sakofsky, Cynthia J., Roberts, Steven A., Malc, Ewa, Mieczkowski, Piotr A., Resnick, Michael A., Gordenin, Dmitry A., Malkova, Anna
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274036/
https://ncbi.nlm.nih.gov/pubmed/24882007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.04.053
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