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Repair of base damage within break-induced replication intermediates promotes kataegis associated with chromosome rearrangements
Break induced replication (BIR) is a double strand break repair pathway that can promote genetic instabilities similar to those observed in cancer. Instead of a replication fork, BIR is driven by a migration bubble where asynchronous synthesis between leading and lagging strands leads to accumulatio...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6765108/ https://ncbi.nlm.nih.gov/pubmed/31392335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz651 |
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