Transient dsDNA breaks during pre-replication complex assembly

Initiation of DNA replication involves the ordered assembly of the multi-protein pre-replicative complex (pre-RC) during G(1) phase. Previously, DNA topoisomerase II (topo II) was shown to associate with the DNA replication origin located in the lamin B2 gene locus in a cell-cycle-modulated manner....

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Bibliographic Details
Main Authors: Rampakakis, Emmanouil, Zannis-Hadjopoulos, Maria
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761281/
https://ncbi.nlm.nih.gov/pubmed/19638425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp617
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