Pre-replication complex proteins assemble at regions of low nucleosome occupancy within the Chinese hamster dihydrofolate reductase initiation zone

Genome-scale mapping of pre-replication complex proteins has not been reported in mammalian cells. Poor enrichment of these proteins at specific sites may be due to dispersed binding, poor epitope availability or cell cycle stage-specific binding. Here, we have mapped sites of biotin-tagged ORC and...

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Detalhes bibliográficos
Main Authors: Lubelsky, Yoav, Sasaki, Takayo, Kuipers, Marjorie A., Lucas, Isabelle, Le Beau, Michelle M., Carignon, Sandra, Debatisse, Michelle, Prinz, Joseph A., Dennis, Jonathan H., Gilbert, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082903/
https://ncbi.nlm.nih.gov/pubmed/21148149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1276
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