Mutation signatures specific to DNA alkylating agents in yeast and cancers

Alkylation is one of the most ubiquitous forms of DNA lesions. However, the motif preferences and substrates for the activity of the major types of alkylating agents defined by their nucleophilic substitution reactions (S(N)1 and S(N)2) are still unclear. Utilizing yeast strains engineered for large...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Saini, Natalie, Sterling, Joan F, Sakofsky, Cynthia J, Giacobone, Camille K, Klimczak, Leszek J, Burkholder, Adam B, Malc, Ewa P, Mieczkowski, Piotr A, Gordenin, Dmitry A
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144945/
https://ncbi.nlm.nih.gov/pubmed/32133535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa150
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