APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

APOBEC3A and APOBEC3B, cytidine deaminases of the APOBEC family, are among the main factors causing mutations in human cancers. APOBEC deaminates cytosines in single-stranded DNA (ssDNA). A fraction of the APOBEC-induced mutations occur as clusters (“kataegis”) in single-stranded DNA produced during...

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Sparad:
Bibliografiska uppgifter
I publikationen:Genome Res
Huvudupphovsmän: Seplyarskiy, Vladimir B., Soldatov, Ruslan A., Popadin, Konstantin Y., Antonarakis, Stylianos E., Bazykin, Georgii A., Nikolaev, Sergey I.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2016
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728370/
https://ncbi.nlm.nih.gov/pubmed/26755635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.197046.115
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