APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

APOBEC3A and APOBEC3B, cytidine deaminases of the APOBEC family, are among the main factors causing mutations in human cancers. APOBEC deaminates cytosines in single-stranded DNA (ssDNA). A fraction of the APOBEC-induced mutations occur as clusters (“kataegis”) in single-stranded DNA produced during...

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Détails bibliographiques
Publié dans:Genome Res
Auteurs principaux: Seplyarskiy, Vladimir B., Soldatov, Ruslan A., Popadin, Konstantin Y., Antonarakis, Stylianos E., Bazykin, Georgii A., Nikolaev, Sergey I.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728370/
https://ncbi.nlm.nih.gov/pubmed/26755635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.197046.115
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