APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

APOBEC3A and APOBEC3B, cytidine deaminases of the APOBEC family, are among the main factors causing mutations in human cancers. APOBEC deaminates cytosines in single-stranded DNA (ssDNA). A fraction of the APOBEC-induced mutations occur as clusters (“kataegis”) in single-stranded DNA produced during...

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Detalles Bibliográficos
Publicado en:Genome Res
Main Authors: Seplyarskiy, Vladimir B., Soldatov, Ruslan A., Popadin, Konstantin Y., Antonarakis, Stylianos E., Bazykin, Georgii A., Nikolaev, Sergey I.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728370/
https://ncbi.nlm.nih.gov/pubmed/26755635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.197046.115
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